PREDICTIVTox®
Structure based toxicity information
PREDICTIVTox is a predictive database of structured toxicity information comprising thousands of compounds that have been fully profiled using ACTIVTox®. The broad hepatotoxicity database acts as a guide to synthesize new compounds while minimizing toxic liabilities.
This information solution has been developed in conjunction with MDL Information Systems, a subsidiary of Reed Elsevier, and will soon comprise over 50,000 compounds screened in a multitude of assays at different concentrations.
PREDICTIVTox offers these additional advantages:
- Structure based toxicity information
- Provides a context in which to examine structure-toxicity relationships
- Anchored to 5,000 literature accessible compounds
- Fully searchable on any field
- Rapid visualization of data
No other experimentation system on the market combines the accuracy and speed of ACTIVTox with a broad predictive hepatotoxicity database like PREDICTIVTox. A combined database and testing system provide the information necessary to minimize toxicity while simultaneously maximizing therapeutic effect.
Simple in vitro toxicology assays together with a metabolically active biological system yields structure toxicity relationships that are easily interpreted. The results can be taken further to explore structural and mechanistic hypotheses that can result in molecules that are designed towards minimal drug induced liver toxicity. ACTIVTox can be used as early as library synthesis and as late as lead optimization.
